Zonegran Review – 8 Essential Things to Know

Manufactured by Eisai, Zonegran is indicated for the adjunctive treatment of partial seizures in adults with epilepsy. The manufacturer claims the drug is efficient in both the prevention and the treatment of this medical condition and should be used in combination with other anti-convulsing medication. Eisai was founded in Japan in 1941 and is now a reputable multinational pharmaceutical company.

The drug is an FDA approved prescription medicine. The manufacturer mentions excellent results in clinical trials, which have shown great efficiency in using the drug as an adjunctive therapy. The trials conducted in three multicenter, placebo-controlled, double blind, 3-month clinical trials in 499 patients with refractory partial onset seizures revealed a 27% – 40% median reduction in all partial seizures versus a -1% – 9 % median reduction with placebo.

Bear in mind that Zonegran’s safety and effectiveness in children under 16 years of age has not been proven.

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1) Quick Overview

The drug works through its active substance – Zonisamide, a sulfonamide anticonvulsant used in therapy for adults with partial-onset seizures. Although the exact mechanism of action for Zonisamide is not known, there are multiple potential mechanisms of action that may impact seizure reduction. One theory claims the substance stabilizes the electrical activity in the brain and thus prevents the excessive seizure-causing signals from spreading through the brain. Another one claims it works to balance the levels of GABA, a neurotransmitter responsible for calming the nerve activity in the brain.

Special precautions refer to patients suffering from liver diseases, kidney disease (kidney stones), lung/breathing problems, long-term diarrhea, metabolic imbalance (metabolic acidosis), mental/mood problems (depression, psychosis).

2) What Are Zonegran Ingredients?

Zonegran contains the following ingredient: Zonisamide (active substance)
Inactive ingredients: microcrystalline cellulose, hydrogenated vegetable oil, sodium lauryl sulfate, gelatin and colorants

3) Does Zonegran Work and it is Safe?

It is important to understand that Zonegran isn’t effective for the treatment of seizures on its own. Instead, it is a type of medication that is given in conjunction with others. This is referred to as adjunct therapy. It has been offered with various anti-seizure and anti-epilepsy medications.

The main ingredient in this formulation is zonisamide (Zonegran). The product is sold in capsule forms at different strengths. The amount of it will depend on the needs of the patient.

Many side effects have been reported with the use of Zonegran. This includes drowsiness, dizziness, nausea or vomiting, headaches, irritability, rash, fever, sore throat, dark colored urine, areas of the body that bruise very easily, and insomnia. Anyone who is allergic to sulfa drugs shouldn’t use this medication.

It is crucial only to take the recommended dose of it. Otherwise, the risk of kidney stones developing can occur. Women who are pregnant shouldn’t use Zonegran because it can cause congenital disabilities.

4) What Zonegran Does?

• Good manufacturer reputation
• Excellent results in clinical trials
• FDA approved
• Reasonable price

5) What You Need to Know Before Taking Zonegran

• Serious potential side effects
• Long list of precautions and warnings depending on one’s medical conditions
• Not tested in children under 16 years old

6) How Much Does Zonegran Cost?

Zonegran is a relatively cheap form of anticonvulsant medication. Most insurance programs and prescription plans will cover the cost of it. It is advised to contact the provider of that coverage directly to see what they will cover. There could be a co-pay or a deductible that applies depending on the types of coverage that a person has.

7) Suggested Use

Zonegran may cause serious side effects, such as serious skin rashes (that could lead to death), fever, suicidal thoughts or actions, metabolic acidosis (increased level of acid in the blood), difficulties in attention, memory, thinking and speech.

8) Bottom Line – Does It Really Work?

Zonegran is a rather recently developed anti-epileptic drug that has proven highly efficient in the treatment of partial seizures in adults with epilepsy. The manufacturing company mentions large scale clinical tests which prove its efficiency. The drug is however associated with a list of serious reactions such as skin rush, suicidal thoughts, somnolence, dizziness and cognitive impairment (speech, memory and concentration may be affected).

According to the manufacturer, the elimination half-life of Zonisamide in plasma is approximately 63 hours, thus consistent therapeutic levels in the blood are ensured. A doctor’s consultation is required before starting taking the drug and before deciding to interrupt treatment.

A doctor’s recommendation is required both before starting treatment and in case of intent to interrupt treatment.The drug is available in 25-mg, 50-mg and 100-mg capsules and a month’s supply greatly varies on other medication included in the treatment.

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