Uridine is an element of RNA has has been used in dietary supplements as a pseudovitamin. The manufacturer, Jarrow Formulas, says uridine supports the health and function of liver mitochondria. This is in addition to other potential benefits, especially if you combine this product with others as part of a nootropic stack. The company notes that is generally used as a precursor and not a stand alone supplement. They’ve been around since 1977 and seem very involved in the scientific and academic communities, and most of their supplements have real science backing their benefits. Jarrow is popular and seems quite trustworthy.
Uridine contains the following ingredients: Uridine 5′ – monophosphate disodium salt, Cellulose, magnesium stearate and silicon dioxide, capsule consists of gelatin.
Each capsule contains 250 mg of Uridine 5′-monophosphate disodium salt. Uridine is found naturally in many things, some of which we consume on a regular basis. Studies disagree on the best way to consume uridine, and why it’s important for mental health, but they do agree on the benefits. Multiple studies have found that when you combine uridine with another compound (for delivery of nutrients beyond the blood brain barrier) and certain other nutrients, it can do a lot.
Uridine monophosphate, choline, and DHA combine to form a mental enhancer that’s also effective as an antidepressant. Omega-3 fatty acids like EPA and DHA are essential brain foods as it is, so it’s not hard to imagine that this is accurate. If you take this product with a good fish oil, that seems the best way to see results in a timely manner.
- A good source of uridine. Capsules contain what’s considered to be the best amount, and the formulation of the featured compound seems proper. Uridine monophosphate (UMP) with sodium is one of the better options. If you take 1 to 2 capsules a day, that should be sufficient. You can take up to 3 or 4 capsules a day but it’s not generally recommended.
- Uridine doesn’t do a lot on its own, even though some people want to take uridine and nothing else. While it may have benefits, they aren’t well studied or definitely known to happen. Uridine is best in conjunction with other nutrients. To make Jarrow’s Uridine supplement really effective, you have to buy other supplements, which is slightly inconvenient and cuts into your bank account. One formula tends to be better than juggling multiple products and combining them.
People say they get a lot of benefits from using uridine supplements, especially as part of a nootropic stack. They report more consistent mood, elevated energy and alertness, and decreased brain fog. One person claimed to have quit coffee after taking uridine for a couple of weeks because it was doing more. By itself, there isn’t much research about uridine to show that it’s worth taking just as a uridine supplement – you’ll probably need additional things. If Jarrow Formulas had included choline and Omega-3s in these capsules, it would be a top notch product with a lot of mental benefits.
10yrs or More
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Is Uridine Right For You?
Uridine is a psuedovitamin and nootropic nutrient found in RNA. It’s supposed to support formation of brain synapses and liver mitochondrial function, according to the company behind this product, who is Jarrow Formulas. They’re based out of California and were founded in 1977, then incorporated in 1988. As one of the larger and more popular supplement companies, they seem to have a strong inclination towards acknowledging scientific research and the progress it makes. They have a scientific advisory board and share recent studies on their website. Updating their formulas and having the motto “Superior Nutrition and Formulation” definitely helps them keep their good reputation.
Ingredients of Uridine
Uridine includes the following ingredients: Uridine 5′ – monophosphate disodium salt, Cellulose, magnesium stearate and silicon dioxide, Capsule consists of gelatin.
Effectiveness of Uridine
The only active ingredient is listed as 250 mg of Uridine 5′-monophosphate disodium salt. Uridine is found in mother’s milk, infant milk, beer, and foods like broccoli. A study from Yale found that food is an unreliable source of uridine, because it’s destroyed in the liver and gastrointestinal tract, instead of being absorbed. Some other studies have disagreed on this point. In general, if you want more uridine in your diet, supplements are thought to be a decent option. Formulas, such as those including monophosphate, are more effective than simply including basic forms of uridine.
A combination of Omega-3s and uridine may prevent depression from kicking in. Harvard researchers found this combination to be as equally effective as antidepressants in animal studies. A study with gerbils found an increase in cognitive function when they were fed a combination of uridine monophosphate, choline (a water soluble vitamin), and DHA (an Omega-3 fatty acid). In humans, uridine monophosphate is used as a delivery compound for uridine.
How much to take, and when to take it, isn’t clear. Studies seem to mostly use 500 to 1000 mg, and it’s recommended that you take it with food just in case. There aren’t any known side effects, but it’s best to stay on the safe side.
Bottles last between 30 and 60 days depending on how often you take each capsule. The directions recommend 1 to 2 capsules a day, or as directed by your doctor, and bottles have 60 capsules inside. If you take 1 a day then this is a pretty inexpensive supplement. If you take 2 a day, it’s on the higher side of average.
Does Uridine Work?
Many reviewers say the effects are subtle and without unpleasant side effects. This will be good for those who want a small boost. Some people haven’t noticed any changes at all, so your mileage may vary. Uridine, when transported as part of a compound, can bypass the blood brain barrier and ensure nutrients get to where they need to be. If it’s true that basic uridine isn’t absorbed into the bloodstream properly, as some studies have found, then you’ll need a product like what Jarrow Formulas has developed. If you want extra mileage out of your choline or DHA, this is probably the best option for you.