There are very few supplements out there that get as much attention as memory and brain supplements, and Prevagen is one of those. According to the official website, Prevagen is “the top-selling memory supplement in stores” across the United States. And all that with just one active ingredient: apoaequorin.
Apoaequorin is a patented ingredient claimed to improve memory function in those with very mild cognitive decline. This being said, Prevagen should not be confused with a prescription cognitive aid.
Furthermore, our team of researchers presented us with all the information they found about Prevagen’s patented ingredient, claimed benefits, potential side effects and warnings, scientific studies on the product, price, and more. We’ve compiled their findings here for you today.
1) What Is Prevagen?
Prevagen is a dietary supplement claimed to improve brain and memory health. The company behind this brain supplement is Quincy Bioscience. Their patented formula contains apoaequorin; a protein from jellyfish. According to Quincy Bioscience, this protein helps promote and enhance brain functions. Apoaequorin supposedly improves short-term memory problems and reduces excess calcium levels in the brain.
Apoaequorin has the unique property to facilitate the binding of calcium ions, which is essential given the essential role of this mineral in many bodily processes and functions.
It is well known how our brains protect their cells from degradation by generating a unique protein that controls cellular calcium. If calcium exceeds a certain limit in cells, these cells will be damaged and even destroyed.
Because of the natural aging process, the body generates this protein in smaller amounts, which eventually will lead to increased levels of calcium in cells.
2) Prevagen Claims
Prevagen is generally advertised as a powerful dietary supplement specially designed to improve the function of the brain and mental health.
According to WebMD, “early research shows that taking 10 mg of apoaequorin (Prevagen, Quincy Bioscience) daily for 90 days might improve forgetfulness, word recall, and the need for reminders in some people. But, this research is of lower quality.”
The same WebMD reports that “early research shows that taking 10 mg of apoaequorin (Prevagen, Quincy Bioscience) daily for 90 days might improve some measures of mental function in older adults.”
On the other hand, according to the journal Advances in Mind-Body Medicine, “apoaequorin and improvements on a quantitative measure of cognitive function.” The research went on to state the ingredient is “well-tolerated,” and addresses declines in cognitive function.
3) Who Is the Company Behind Prevagen?
Quincy Bioscience is a biotechnology company based in Madison, Wisconsin, that focuses on the discovery, development, and commercialization of novel technologies to support cognitive function and other normal health challenges associated with aging.
726 Heartland Trail
Madison, WI 53717
4) Prevagen Ingredients
The active ingredient is:
- Apoaequorin (10 mg per capsule)
Other ingredients are:
- Microcrystalline cellulose
- Vegetable capsule (cellulose, water)
- Acacia (gum arabic)
- Casein Peptones
- Corn starch
- Magnesium stearate (vegetable source)
- Medium chain triglycerides (vegetable oil)
- Tricalcium phosphate
Contains: Milk, soy, tree nuts (coconut) derived ingredients.
5) The History of Prevagen
Apoaequorin was obtained in 1962 from a specific type of jellyfish that glows. When the protein is exposed to calcium, apoaequorin and calcium bind and a blue light is created.
Over the past 40 years, apoaequorin has been used to study how calcium works inside cells. Starting with 2007 apoaequorin has been manufactured on a larger scale for use in the dietary supplement Prevagen, which is now available worldwide.
6) Does Prevagen Work?
The official website links to four different studies in order to support the company’s claims regarding this product. First, is the “Madison Memory Study – A Randomized, Double-Blinded, Placebo-Controlled Trial of Apoaequorin inCommunity-Dwelling, Older Adults,” a clinical trial sponsored by Quincy Bioscience.
The other three are safety studies and have been conducted on the core ingredient, apoaequorin:
- “Safety assessment of Apoaequorin, a protein preparation: subchronic toxicity study in rats”
- “Safety assessment of the calcium-binding protein, apoaequorin, expressed by Escherichia coli.”
- “Subchronic toxicity of lyophilized apoaequorin protein powder in Sprague-Dawley rats”
Note that none of the three safety studies from above have been conducted on humans.
According to the Federal Trade Commission, “apoaequorin is rapidly digested in the stomach and broken down into amino acids and small peptides like any other dietary protein.”
7) Benefits of Prevagen
According to Quincy Bioscience, this formula was specially designed and built to support healthy brain function, sharper mind, and clearer thinking. Furthermore, the company claims that Prevagen will improve certain aspects of cognitive function over 90 days.
Prevagen may be a good product for mild problems, expressly ones due to aging. It may be fitting for adults who want to improve short-term memory and overall brain health.
According to an article published by the University of California Berkley, “The primary ingredient in Prevagen is a synthetic version of apoaequorin, and it has the potential to improve the function of aging neurons and, therefore, to enhance memory and cognitive function.”
8) Variations of Prevagen
This dietary supplement is available in several variations:
- Regular Strength 30 Capsules – 10 mg apoaequorin per capsule
- Regular Strength 30 Chewables – 10 mg apoaequorin per tablet
- Extra Strength 30 Capsules – 20 mg apoaequorin per capsule
- Extra Strength 30 Chewables – 20 mg apoaequorin per tablet
- Regular Strength 60 Capsules – 10 mg apoaequorin per capsule
- Professional Strength 30 Capsules – 40 mg of apoaequorin per capsule
9) How Much Does Prevagen Cost?
The Prevagen price varies based on the retailer you buy it from and based on the product variation. On the official website, the price for a bottle of Prevagen Regular Strength is $39.95, for a bottle of Prevagen Extra Strength is $59.95, and for a bottle of Prevagen Professional Strength is $89.95
You can get it for similar prices on Amazon, but with the added benefit of free shipping for orders placed from within the United States.
10) Where To Buy Prevagen?
Prevagen is available through the official website. It can also be purchased from numerous retailers, including:
- The Vitamin Shope
- Botanic Choice
Additional retailers are listed on the supplement’s website.
11) How To Take Prevagen?
Prevagen offers the best results when is taken daily. The recommended dose is one capsule or chewable tablet in the morning with or without food.
12) Side Effects and Warnings
The official website states that “Prevagen is very safe and extremely well-tolerated. There are no known contraindications with any supplements or medications.” No clinical data are showing the active ingredient apoaequorin causes side effects. The only remarks of side effects are in some Prevagen reviews.
Some people who have taken apoaequorin have reported potential side effects. Some of the most commonly reported side effects were:
- Difficulty sleeping
There have also been a smaller number of reports of more serious potential side effects such as heart and nervous system-related events.
13) What are Prevagen Alternatives?
There are many alternatives to Prevagen.
Prevagen Extra Strength is a stronger (and more expensive) version of the original formula; usually described throughout many reviews online as an advanced “brain enhancement supplement.” Claimed benefits include:
- Promote Clearer Thinking
- Increase Mental Function
- Improve Overall Brain Health
Lumonol Wisdom is the newest brain supplement developed by Avanse Nutraceuticals. Lumonol Wisdom contains Noopept, a compound claiming to provide a variety of asserted benefits including:
- Increased memory capacity
- Improved memory recall
- Increased mental processing speed
- Improved ability to learn
- Enhanced mood
Focus Factor is a dietary supplement supposedly helping to enhance mental focus and clarity. Focus Factor ingredients include:
- Beta carotene
- Vitamins – B6, B12, D3
Alpha Brain can be another decent alternative. This brain supplement’s formula is focused on improving memory, concentration, and energy. Alpha Brain ingredients include:
- Huperzine A
- Alpha GPC
14) What Users Are Saying
“At first I thought it helped clear my mind and help me concentrate. However, after a while, I seemed to be more irritable”
“I’m on my second bottle of Prevagen. I have noticed some memory improvement. I intend to continue using this product.”
— John Hume
“Seems to work because I have noticed gradual changes over a two week period. It’s worth a try given what can be gained.”
Prevagen is advertised as one of the leading brain supplements on the market. There are even studies supporting the benefits of the active ingredient apoaequorin. Age, itself, has some influence on the human body’s decline and Prevagen may be useful in helping brain function but with the cited shortcomings.
The fact that Prevagen is one of the best selling brain supplements in the United States can’t be overlooked. While part of its success might be due to the aggressive marketing campaign Quincy Bioscience is using to push their product, Prevagen may still be a good solution for those looking for a decent brain supplement.