BrainReference is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.
We aim to provide consumers with helpful, in-depth information about brain health products. Whether we make money or not on a certain page does not influence the core mission of our writers and medical reviewers, which is to publish content that is accurate and informative.
All product names, logos, and brands are the property of their respective owners.
For more information, see our full Advertising Disclosure
NeuroSAMe Review – 8 Things To Look For
NeuroSAMe is a dietary supplement designed for people who suffer from depression. The company behind this product is Amen Clinics, which was founded more than 30 years ago by Dr. Amen. He has a very prestigious career, being a famous physician, psychiatrist and a well-known author. Considered one of the best researchers in the field of brain imaging, Dr. Amen has contributed to the developing of his company’s dietary supplements. However, his use of brain SPECT scans for psychiatric and neurological diagnosis of patients has generated some criticism. Amen Clinics claims to offer the most advanced nutritional help and they provide programs to help people achieve an optimal health.
According to its manufacturers, NeuroSAMe was made for depressive individuals and it is based on SAMe, which is S-Adenosyl L-Methionine, a naturally occurring metabolite found in the body that is produced from the amino-acid methionine. This nutrient is the most active methyl donor and is involved in the synthesis of the neurotransmitters serotonin, dopamine, and epinephrine, which play an important role in mood regulation and energy.
Moreover, the company claims that NeuroSAMeis superior to other products on the market due to its stability resulted from the nitrogen blister packs and maximized bioavailability by an enteric coating, as it is very sensitive to degradation from air and moisture.
1) Quick Overview
As stated before, the key ingredient in NeuroSAMe is S-Adenosyl L-Methionine or SAMe. One of its many functions consist in the production of melatonin, which the sleep hormone. It is also involved in the cell membrane stabilizing phospholipids that support the proper cellular communication and are essential to brain health. Deficiencies in this metabolite are linked to depression and neurovegetative disorders. While supplements based on this element shown imprevement for symptoms of depression, it also contributes to joint inflammation and pain reduction, sleep quality, improving the liver detoxification process, suppressing appetite for those who want to lose weight and increase glutathione levels, which are very important in neuroprotection. Although SAMe has been proven to be generally safe, there is a minor risk of mania for certain individuals.
2) Ingredients of NeuroSAMe
NeuroSAMe contains the following ingredients: Vitamin B6 (Pyridoxine HCL), Folic Acid, Vitamin B12 (Cyanocobalamin), S-Adenosyl L-Methionine (as Disulfate Monotosylate), Microcrystalline cellulose, croscarmellose sodium, methacrylic acid co-polymer, colloidal silicon dioxide, magnesium stearate, triethyl citrate, stearic acid, citric acid, ascorbic acid, and riboflavin.
3) Is NeuroSAMe Right for You?
The main ingredient in this formula is S-Adenosyl-L-Methionine or SAMe as it is often referred to in the literature. SAMe enjoys many benefits for the body, including the fact that it produces Melatonin, which is the sleep hormone. It also contributes to cell membrane health, stabilizing phospholipids that support optimum cellular communication and are essential to the nervous system. Low levels of this metabolite may lead to depression and near vegetative disorders.
SAMe is known as the most important methylating agent in the brain – it donates methyl groups to molecules for optimum functioning. Because methyl group deficiencies have been clinically associated with depression and other brain diseases, it is important that methyl donors such as SAMe do their job to maintain active hormones, neurotransmitters, and phospholipids which in turn ensure that the brain is in fine condition.
Besides being a remedy for symptoms of depression, SAMe is also involved in treating joint inflammation and pain, improving sleep quality and liver’s detoxification process. However, excessive amounts of SAMe may lead to mania in certain individuals.
Although the body produces healthy levels of this compound, deficiencies may appear because of aging, poor diet, inflammatory states, emotional stress or genetic polymorphisms. Prevention measures include boosting the supply of enzymes cofactors such as SAMe, magnesium or B-vitamins. This is why the formula also contains Vitamins B6, B12, and folate as cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine. Vitamin B6 is an essential vitamin for the production of amino acids, glucose, and fatty acids. It is also involved in the production of new neurotransmitters such as serotonin, norepinephrine, GABA or epinephrine.
It is stated that this dietary supplement should be used once or twice daily, preferably on an empty stomach. People who suffer from bipolar disorders should avoid this supplement, unless under professional medical supervision.
4) NeuroSAMe Health Benefits
- The product is stated as being unique, due to its stability in the nitrogen blister packs and maximized bio-availability by an enteric coating
- One bottle may be enough for one month’s supply, as it contains 30 tablets
- There are specific use directions, with smaller dosage in the beginning and increasing it after awhile
5) NeuroSAMe Product Warnings
- There are no testimonials available on the website
- The product has not been reviewed by the FDA and it was not clinically studied
- SAMe may produce certain side effects such as nausea, vomiting or even mild insomnia if excess doses are used
6) NeuroSAMe Cost
NeuroSAMe is an averaged priced supplement. One bottle contains 30 tablets, which may be enough only for one or maximum two months’ supply, for the common user. The company works with an auto ship convenience program, meaning that a lot of time and effort are saved for customers who chose this option. You can safely order online from the manufacturer’s website, but it is highly recommended for you to download the fact sheet first, to find out more about the supplement. Refunds are issued on a case by case basis within 30 days of delivery of your order. You could investigate the market for similar products before purchase.
7) Suggested Use
The body may produce normal or average levels of this metabolite, but aging, dietary deficiency, inflammatory states, emotional stress or genetic polymorphisms may require a higher demand. Increasing the supply of enzymes co-factors such as SAMe, magnesium or B-vitamins is thought to be a great help for enzymes deficiency, which is normally related to aging. The formula also includes Vitamins B6, B12, and folate as cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine. This dietary supplement should be taken once or twice daily, preferably on an empty stomach. It is not recommended for those who suffer from the bipolar disorder, unless under professional medical supervision.
NeuroSAMe may support the reduction of depression associated symptoms, improving sleep quality, balancing brain chemistry and for overall health of the brain. The tablets are enterically coated in order to prevent its breakdown by stomach acidity and support an intact absorption in the small intestine. There are no available testimonials for this product at the moment on the manufacturers website and no mentioned clinical trials. This product does not contain wheat, soy, corn, yeast, milk, or gluten, which makes it suitable for those who require non-allergenic formulas. It is highly recommended you seek for medical advice prior to the administration of NeuroSAMe.NeuroSAMe has proven beneficial for many, we also suggest taking a look at other supplements designed for your specific ailments.
Without a doubt, HCF® Happy, Calm & Focused is one of the top Amino Acids [Blend] brain supplements for attention challenges we've encountered so far. Starting in 2001 and 45 countries worldwide, the company has been dedicated to only the foundational building blocks of life; amino acids, vitamins, and minerals, unlike the conventional high-dose 'all-in-one' or artificially stimulating/inhibiting nootropics found on the market today for promoting attention, calm and focus.
|NeuroSAMe Customers Related Products:||
10+ Yrs Proven
|HCF Happy, Calm & Focused
NeuroSAMe - Frequently Asked Questions
NeuroSAMe includes the following ingredients: S-Adenosyl-L-Methionine (as Disulfate Monotosylate),Vitamin B6 (Pyridoxine HCL), Folic Acid, Vitamin B12(Cyanocobalamin), Microcrystalline cellulose, croscarmellose sodium, methacrylic acid copolymer, colloidal silicon dioxide, magnesium stearate, triethyl citrate, stearic acid, citric acid, ascorbic acid, and riboflavin.
NeuroSAMe is dietary supplement designed for people who suffer from depression. The company behind the product is Amen Clinics, which was developed by Dr. Amen roughly 30 years ago. The formula is based on the substance SAMe, which stands for S-Adenosyl L-Methionine, a naturally occurring metabolite found in the body that is produced from the amino acid methionine.
Although SAMe has been proven to be generally safe, there is a minor risk of mania for certain individuals, so you should consult with your healthcare practitioner prior to use.
NeuroSAMe may be beneficial for decreasing depression symptoms, enhancing sleep quality, balancing brain chemistry and for the general health of the nervous system. The tablets are empirically coated for the prevention of breakdown by stomach acidity and support an intact absorption in the small intestine. Unfortunately, there are no available testimonials for this product on the manufacturer's official website, nor elsewhere and no public clinical trials can be accessed. According to its makers, this product does not contain wheat, soy, corn, yeast, milk, or gluten, which makes it suitable for those who need non-allergenic formulas. We recommend you to seek medical advice before the consumption of this dietary supplement.