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Drenamin Review – 12 Essential Things to Know
If anything is more constant in present-day life, then it is anxiety and stress. Far too often, it is because of relentless schedules, unhealthy behaviors, and habits. Overall, stress is affecting our potential more than we care to admit.
Drenamin made by Standard Process is advertised as a natural stress-relieving and support supplement. The formula contains several animal adrenal extracts, as well as herbal extracts and vitamins, claimed to support proper adrenal gland function.

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1) Drenamin at a Glance
According to Standard Process, Drenamin is a powerful natural stress reliever. The supplement is intended to support proper adrenal function, relieve stress & anxiety, and enhance the body’s resistance to fatigue, allergies, and illness.[1]
Drenamin also claims to improve energy production, encourage a balanced mood, promote healthy responses to stressors, and provide high amounts of antioxidant Vitamin C.
2) The Company Behind Drenamin
Standard Process has a long and eventful history as a visionary leader in the dietary supplements industry since 1929. According to the official website, the company is guided by a vision to provide wholesome supplements closest to their natural form.
All Standard Process supplements are formulated from whole foods found in nature (whole food extracts, animal tissue extracts, botanicals, whole food isolates, and concentrates) and are prepared to conserve the nutritive value.
In 1926, Dr. Royal Lee understood the negative impact the average American diet had on general health. He acknowledged that processed foods exhausted our food sources of rich nutrition once found in them. Dr. Lee dedicated his entire life to developing a more advanced system for producing whole-food-based supplements.[2]
Standard Process offers 300+ nutritional supplements, including a separate range of vegetarian and gluten-free supplements. Some of their top products are:
- SP Complete – Whole food nutrition;
- Catalyn – Vitamin based supplement and the first product developed by founder Dr. Royal Lee;
- Immuplex – Immune system support;
- Cardio-Plus – Cardiovascular support;
- Congaplex – Immune system support.
How to contact Standard Process company:
- Website: standardprocess.com
- Phone: 800-558-8740
- Fax: 800-438-3799
- Headquarters: 1200 W. Royal Lee Drive, Palmyra, WI 53156
- Email: info@standardprocess.com
3) Details on Drenamin Ingredients and Uses
Drenamin contains the following active ingredients:
- Riboflavin 1 mg
- Vitamin C 9 mg
- Vitamin B6 0.3 mg
- Niacin 12 mg
- Proprietary Blend [bovine liver, calcium lactate, rice (bran), porcine stomach, bovine adrenal, nutritional yeast, choline bitartrate, bovine adrenal PMG extract, alfalfa extract, magnesium citrate, oat flour, buckwheat (seed), dried buckwheat (leaf) juice, para-aminobenzoate, mushroom, bovine bone, allantoin, veal bone, porcine brain, sunflower lecithin, sweet potato, rice (bran), and Vitamin E (sunflower)] 730 mg
Other ingredients include honey, niacinamide, nutritional yeast, organic dried alfalfa (aerial parts) juice, cellulose, ascorbic acid, and organic dried buckwheat (aerial parts) juice.
4) Does Drenamin Work and it is Safe?
The adrenal glands sit on top of your kidneys and release several essential hormones.[3] Adrenal glands are also responsible for producing cortisol, a stress-related hormone that regulates blood sugar and energy.[4]
When you’re experiencing increased stress, the adrenal glands release cortisol due to a change in blood pressure and a slower immune system. Those experiencing anxiety or chronic stress may be over-working the adrenal glands, resulting in less cortisol being produced.[5]
This phenomenon is called “adrenal insufficiency.” Adrenal fatigue is often considered a milder form of adrenal insufficiency.
According to some experts,[6] adrenal fatigue is associated with some easily recognizable symptoms, such as:
- Nervousness
- Chronic fatigue
- Body aches
- Digestive issues
- Low blood pressure
- Light-headedness
- Hair loss
- Weight loss
However, other experts consider that there are no scientific studies that can prove the existence of such a thing as “adrenal exhaustion.”[7][8]
Let’s also take a quick look over some core ingredients in Drenamin.
Porcine brain – The term “porcine” comes from a Latin root, porcus, which means “pig.” The porcine brain extract is traditionally believed to support and enhance cognitive function.
A study[9] published in the American Journal of Applied Sciences examined porcine brain potential in male Wistar rats. The results showed that administering low doses of the porcine brain extract may improve brain functions, including the rats’ memory deficit, motor performance, and neurological score.
Choline bitartrate belongs to the Vitamin B family, and according to several studies, it is essential for synthesizing acetylcholine, a necessary neurotransmitter for memory-related brain functions.[10]
Magnesium citrate is widely available in nature and is an active compound of magnesium. Magnesium citrate breaks down inside the body into elemental magnesium. Research shows that magnesium citrate may be useful to treat major depression and brain injuries.[11][12]
Para-aminobenzoate (PABA) is found in folic acid and several foods like milk, meat, and eggs. While para-aminobenzoate is an essential nutrient for some animals, more research is needed to demonstrate the same benefits in humans.[13]
Shiitake Mushroom is a native of East Asia and an excellent source of fiber. Shiitake mushrooms contain an element called Ergothioneine (ET).[14] According to Science Daily[15], high intakes of ET may improve cognitive health and lower the chances of mild cognitive impairment (MCI).
Reishi Mushroom is a staple in Chinese medicine for its range of health benefits. Research done on rats showed that the mushroom could prevent brain cells’ loss due to oxidation, which is a common sign of Alzheimer’s disease.[16]
However, more evidence is needed to rate reishi mushroom usefulness for Alzheimer’s disease. Early research indicates that taking reishi mushroom powder does not improve memory or quality of life in people suffering from the disease.[17]
5) Drenamin: Pros and Cons
Drenamin claimed[18] benefits include:
- Supports immune system response function;
- Supports a healthy response to everyday environmental stresses;
- Promotes healthy adrenal gland function;
- Supports a balanced mood;
- Maintains energy production;
- Includes a blend of core ingredients from Cataplex G, Cataplex C, and Drenatrophin PMG;
- It is a good source of Vitamin B6 and antioxidant Vitamin C.
6) Potential Side Effects from Drenamin Ingredients
Standard Process does not mention any potential side effects. Nevertheless, there may be some adverse effects related to Drenamin’s ingredients.
For instance, the powdered form of reishi mushroom may be unsafe when taken by mouth for more than one month because the powdered form has been associated with toxic effects on the liver.
Side effects of Shiitake mushroom[19]:
- May be harmful in blood disorder conditions
- It may worsen some autoimmune disorders like rheumatoid arthritis and lupus
Side effects of Reishi mushroom[20]:
- Dryness of the mouth or throat
- Upset stomach
- Itchiness
- High doses of mushroom powder may increase bleeding among people with bleeding disorders
Side effects of Para-aminobenzoate[21]:
- Nausea
- Skin irritation
- Loss of appetite
- Vomiting
- Diarrhea
7) What You Need to Know Before Taking Drenamin
Standard Process doesn’t mention any warnings or health implications mentioned, other than the standard recommendation that pregnant or nursing mothers should consult with a healthcare provider before taking Drenamin.
There isn’t enough information available about the safety of adrenal extract when taken by mouth. However, according to WebMD[22], people with a low immune system function, or people taking prescriptions to prevent their body from rejecting an organ transplant, should not use supplements containing animal extracts.
8) Where to Buy Drenamin Online?
You can purchase Drenamin on the Standard Process official website. The supplement is also available for purchase on Amazon, eBay, Walmart and is sold by individual practitioners.
9) Drenamin Price
There are two price options based on the quantity:
- A 90-tablets bottle retails at $14.50
- A 360-tablets bottle retails at $45.00
On Amazon, the supplement is priced at about $17.40.
At the recommended dose of three (3) tablets daily, a 90 tablets bottle will last for a month.
10) Directions For Taking Drenamin
For adults, take three (3) Drenamin tablets before meals or as directed.
11) What the Customer Drenamin Reviews Say
"My Herbalist gave me this for extreme fatigue; it makes all the difference in the world! Before, I could do only self-care, and little else but couch-duty... now I live a nearly-normal life!" [Read full review]
---Janette
"Many moms I know use these, so I decided to try. Basically, it's organ meat and is really good for anxiety. I don't typically suffer from anxiety, but they seem to give you a more relaxed, euphoric feel. My guess is the organ meats are highly nutritional." [Read full review]
---Camille A.
"I have used this product for a long time and can attest that it does have a positive effect on calming your nerves and feeling more tranquil. It's made of pure whole food - a trusted thing I like about Standard Process products." [Read full review]
---June C. Dasilva
12) Our Final Take On Drenamin
While Drenamin claims to relieve stress, there has been little research to validate the allegations or the benefits of animal extracts for stress, anxiety, and even better cognitive function.
It is also worth mentioning that taking adrenal supplements your body doesn’t need may lead to unwanted consequences. Furthermore, according to some health experts, when/if you stop taking the supplements, your adrenal glands will need months to recover.
On the other hand, Standard Process is a reputable American brand of dietary supplements with an A+ rating given by the Better Business Bureau (BBB). Customers trust the brand, and Drenamin has been used in clinical practice since 1935. All these lend to good credibility.
A calm and focused mind is fundamental for overall health. Hence, finding the best supplement that promotes these benefits is a big step forward towards cognitive well-being.
When it comes to emerging standards in the brain supplementation industry, HCF® Happy, Calm & Focused is one of the highest praised products we've seen in years. Its unique FQ formula (15+ high-purity, nutraceutical-grade amino acids, and associated neuro-nutrients) offers a lot in supporting mood, energy, focus, and attention.
Plus, since you’re a BrainReference reader, you can take advantage of a free sample of HCF® Happy, Calm & Focused for a limited time.
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Things Customers Want to Know about Drenamin
- Recent:
Drenamin contains the following active ingredients: Riboflavin, Vitamin C, Vitamin B6, Niacin, and Proprietary Blend [bovine liver, calcium lactate, rice (bran), porcine stomach, bovine adrenal, nutritional yeast, choline bitartrate, bovine adrenal PMG extract, alfalfa extract, magnesium citrate, oat flour, buckwheat (seed), dried buckwheat (leaf) juice, para-aminobenzoate, mushroom, bovine bone, allantoin, veal bone, porcine brain, sunflower lecithin, sweet potato, rice (bran), and Vitamin E (sunflower)].
Drenamin made by Standard Process is advertised as a natural stress-relieving and support supplement.
Standard Process does not mention any potential side effects. Nevertheless, there may be some adverse effects related to Drenamin's ingredients. Some users may experience dryness of the mouth or throat, upset stomach, itchiness, nausea, skin irritation, loss of appetite, vomiting, or diarrhea.
You can purchase Drenamin on the Standard Process official website. The supplement is also available for purchase on Amazon, eBay, Walmart and is sold by individual practitioners.
There are two price options based on the quantity: a 90-tablets bottle retails at $14.50, while a 360-tablets bottle retails at $45.00.
Drenamin is intended to support proper adrenal function and relieve stress, anxiety, and enhance the body's resistance to fatigue, allergies, and illness.
There is little scientific evidence to support Standard Process's claims for this dietary supplement. However, customers trust the brand and Drenamin has been used in clinical practice since 1935. All these lend to good credibility and may indicate that the product actually works as advertised.
If under treatment with ANY form of prescription medication, we strongly recommend consulting with your doctor or pharmacist before taking Drenamin.
You can take Drenamin with your daily multivitamins. However, we strongly recommend consulting with a medical doctor before starting on several different dietary supplements, all at once.
Drenamin is not recommended to children and teenagers under 18.
Drenamin contains several animal extracts. Adrenal extracts are UNSAFE when injected, and there isn't enough information available about the safety of adrenal extract when taken by mouth. We recommend consulting your healthcare provider before taking any dietary supplement containing animal extracts.
Drenamin was designed to support proper adrenal function, relieve stress & anxiety, improve energy production, encourage a balanced mood, promote healthy responses to stressors, provide high amounts of antioxidant Vitamin C, and enhance the body's resistance to fatigue, allergies, and illness.
Pregnant or nursing mothers should not take Drenamin unless recommended by a medical professional.
For adults, take three (3) Drenamin tablets before meals or as directed.
You can contact the Standard Process customer service by phone at 800-558-8740 (toll-free number) or by email at info@standardprocess.com.
Standard Process doesn't accept returns, but you may still be able to receive a full refund by contacting the customer support department. If you purchase Drenamin from another store (i.e., Amazon or Walmart), you shouldn't have any issues asking for a refund, as all these large retailers have strong customer and return policies.
Some Drenamin users complained about experiencing mild side effects after taking the product. Others were unhappy about the retail costs, considering that the product can also be purchased from health care practitioners at a lower price.
Drenamin reviews and testimonials on Amazon are overwhelmingly positive. The supplement is rated 4.8 out of 5 (757 ratings), 94% of the users rating the product with at least 4 stars.
Symplex F is made by Standard Process, a family-owned nutritional supplement company founded by Dr. Royal Lee in 1926.
Drenamin was suggested to me in 2007 by my chiropractor. I saw and felt the results within the first week. Since this time, Drenamin has been my go-to supplement when feeling overstressed and low on energy/fatigued due to stress. You may also see a drop in your waistline as it helps regulate cortisol. I’m actually out here on the Internet today to buy another bottle of Drenamin. I’m a 13-year fan of this product. I’ve never had any sided effects from taking Drenamin. I’ve recommended to family and friends. Highly recommended.
my acupuncturist suggested I try this. I take 5 in a.m. and 4 in pm – which is a lot to take, but after about 3 days of taking it I have a lot less fatigue and mental clarity. I’m gonna stick with it. helps my overall mood if i take it regularly
I see that oat flour is mentioned in the ingredients of Drenamin. I have used this product briefly, and since I am gluten sensitive, I specifically looked to find the GLUTEN FREE label before using. Is the oat flour gluten free?
My doctor recommended this supplement against my adrenal function problems. I noticed the results after the first two weeks and since then I take it regularly. I no longer feel tired all day long, and I am now able to finish my work in time. This is a great product and I recommended to all those who are under a lot of stress.
This product is giving me the extra energy I need every day and helps me stay positive and mentally focused on my daily tasks. I definitely see an improvement in the way I manage stressful situations, which is exactly why I wanted to try this product in first place.
I have had no side effects from Drenamin. It immediately helped me with sleeping and joint pain after sleeping. My sister and bro-in-law turned me on to this supplement after they praised their joints didn’t hurt in the morning so I gave it a try and was surprised since I usually don’t have success with supplements and other aids.
I just read your review of Drenamin. I am starting it today. Have you had any bad side effects?