Deplin is a prescription drug recommended as an antidepressant and antipsychotic. The drug is produced by Pamlab, a biomedical company specialized in developing natural medicine of the highest quality. The company claims to provide personalized solutions that safely approach distinct nutritional requirements for people suffering from various health concerns. Their particular interest in studying metabolic imbalances and the genomic factors that affect certain types of people is what distinguishes them from competition.
The formula is marketed as a prescription vitamin based on the active form of a naturally occurring substance in the human body called Folate. This form is known as L-methylfolate and is an essential substance for the formation of healthy DNA and prevention of DNA damage. Deplin is prescribed to treat different conditions caused by a deficiency in this vitamin including low plasma and low blood cell folate, and other conditions such as mood related disorders. L-methylfolate is included in the trimonoamine modulators category of antidepressants and is particularly needed by the body for proper synthesis of important neurotransmitters like Serotonin, Norepinephrine and Dopamine, substances known to affect the sense of well-being and the body’s response to stress. Among the advertised benefits, the manufacturer mentions increased alertness, mood, and concentration, enhanced ability to take initiative, motivation, and increased sociability.
The formula is recommended only to adults. Official information can be achieved after completing the form available on the manufacturer’s webpage.
Deplin contains the following ingredients: Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algal Oil), Glucose Syrup Solids,
Mannitol, Sodium Caseinate (milk), Soy Protein, High Oleic Sunflower Oil, 2% or less Sodium Ascorbate, Tricalcium Phosphate, Tetrasodium Diphosphate, Natural Flavors, Soy Lecithin, and Mixed Natural Tocopherols and Ascorbyl Palmitate), Gelatin (Kosher Ko), L-methylfolate Calcium, Magnesium Stearate Vegetable Source), Titanium dioxide(color), FD&C Yellow #6(color), FD&C Red #40(color), Propylene Glycol, and Povidone.
Deplin is based on a single active ingredient, the natural form of Folic acid known as L-methylfolate. This is claimed as the only form to cross the brain blood barrier, which makes the product effective in regulating levels of important neurotransmitters associated with mood. The active substance is claimed to be a medical food, which is different from both dietary foods and drugs. The compound is known to be used in the normal formation of genetic material, particularly helpful in the case of fetuses for the prevention of DNA mutations such as neural tube defects. Another important function is in the synthesis of the neurotransmitters Serotonin, Norepinephrine, and Dopamine. Serotonin is known to particularly influence the sense of well-being and happiness, regulate mood, appetite, and sleep, and improve memory and learning skills. Dopamine is vital for neural transmission and is particularly linked to memory related skills and motivational actions.
Norepinephrine is an excitatory neurotransmitter also linked with mood regulation. Imbalance in this substance has been shown to result in increased anxiety, sleeping problems, decreased focus and low energy. Adequate levels of Folate are considered highly important for mental and cognitive health and maintenance of proper levels of nutrients in the brain. Reduced Folic acid levels may also lead to cardiovascular problems (including blood clots) and schizophrenia symptoms.
Deplin medication is not recommended for pregnant, planning to become pregnant or breast-feeding women, patients who are under any other treatment, people with known allergies or low levels of vitamin B9. Drug interactions have also been reported, including with non-steroidal anti-inflammatory drugs, barbiturates, and other drugs. A full list of interactions can be provided by a specialized healthcare practitioner. The most common Deplin side effects are allergic reactions with symptoms like rash and itching, difficulty breathing, swelling of the mouth, lips, face or tongue, and tightness in the chest.
Deplin dosage varies depending on the condition and should be recommended by a healthcare specialist.
- The formula is manufactured by a reputable producer
- The active ingredient is able to cross the blood-brain barrier
- A large number of consumers support the formula’s effectiveness in treating symptoms of severe depression and other mood related disorders
- The formula has been clinically studied
- Deplin’s active ingredient is the natural form of folic acid
- The formula is not recommended without the prior consent of a healthcare specialist
- Potentially dangerous drug interactions and Deplin side-effects are possible (immediate medical attention is recommended in these cases)
- Deplin cost for a month supply is high
- Deplin ingredients may cause allergic reactions (special precaution is advised for individuals with known allergies to any of these substances)
The answer to the question “What is Deplin” and how it works is complex. Deplin is a formulation based on the therapeutic action of a bio-available form of the vitamin B9. The formula is offered as an additional support for those who are on antidepressants, suffer from schizophrenia or are unable to convert dietary foliate into L-methylfolate. The formula is advertised as a natural sourced product that has a major advantage to synthetic-based dietary supplements and formulations: that of crossing the BBB. Deplin for depression is very popular among users of antidepressants and is claimed to have helped patients who have been struggling for years with severe depression symptoms and other conditions. Clinical trials have shown that the combination of Deplin medication with SSRI drugs was effective in considerably lowering symptoms of major depressive disorder as compared to placebo drugs.
Deplin is not indicated for several categories of people including those with hypersensitivity to any of the ingredients listed. Moreover, given all the potential dangers that may occur in case of incorrect administration or any specific health issues of each consumer, it is highly recommended not to use this formula unless a doctor has given its consent and only in the recommended doses.
10yrs or More
|HCF Quality (4.8)||(4.8)|
Deplin is a prescription drug often recommended as an antidepressant and antipsychotic. The manufacturer of this product is Pamlab, a company that offers several brands of such products as well as nutritional supplements advertised as high quality formulations.
This product is based on the active form of folate known as L-methylfolate. It is a vitamin based drug that acts as a natural antidepressant due to its ability in modulating the activity of several major neurotransmitters related to mood disorders.
The relation between Deplin and depression has been widely researched. Deplin benefits include increased mood, alertness, motivation and sociability. Deplin medication is advised in various health concerns including when a severe deficiency in folic acid occurs. Deplin ingredients include several other active substances and a relatively large number of inactive compounds. Deplin side effects often include an allergic reaction.
The suggested dosage of such a drug is variable, depending on the condition of the user and its particular health issues.
Developed and manufactured by Pamlab, Deplin is a prescription medication that was specially created to help people with various forms of depression. According to the manufacturer, “dietary management of depression with Deplin regulates all three monoamine neurotransmitters associated with mood by providing the increased requirements for Folate in the brain.” This claim appears to be supported by some clinical studies, but our review will take a closer look at whether Deplin is an excellent solution for patients struggling with depression.
Is Deplin Right For You?
Deplin is a prescription medication whose primary purpose is to help patients suffering from various forms of depression. This product is manufactured by Pamlab (Pan American Laboratories), a growing company specialized in formulating “prescription medical foods.” The company has over 50 years of experience in developing and producing this type of supplements.
A quick research into the company’s background has revealed mostly positive feedbacks. Given these facts, we believe that Pamlab is a trustable supplier of prescription formulations. According to their claims, and to numerous online testimonials, Pamlab can deliver high quality and efficient products.
The official Deplin web page states that the formulation works by regulating all three monoamine neurotransmitters associated with mood, as well as by providing proper amounts of folate to the brain. Sounds complicated, but in simpler terms, Deplin artificially stimulates neurotransmitter synthesis to reduce the symptoms associated with various forms of depression.
However, while prescription medications may be the right route for patients with severe forms of depression, it should not be the first or only choice for most patients.
Ingredients of Deplin
DEPLIN 7.5mg contains the following ingredients: Dibasic Calcium Phosphate Dihydrate, Silicified Microcrystalline cellulose 90, Silicified Microcrystalline cellulose HD 90, Opadry II Blue 85F90748 (Polyvinyl alcohol, Titanium Dioxide [color], PEG 3350, talc and FD&C Blue #2[color]), L-methyl folate Calcium, magnesium stearate (vegetable source), and carnauba wax.
DEPLIN 15mg contains the following ingredients: Dibasic Calcium Phosphate Dihydrate, Silicified Microcrystalline Cellulose 90, Opadry II Orange 85F43102, (Polyvinyl Alcohol, Titanium Dioxide [color], PEG 3350, Talc, FD&C Yellow #6[color], FD&C Yellow #5[color], FD&CRed #40[color] and FD&C Blue #2[color]), L-methylfolate Calcium, magnesium stearate (vegetable source), and carnauba wax.
Effectiveness of Deplin
First of all, we would like to point out that all antidepressant drugs are altering the composition of your brain, creating an unnatural environment. That is the exact opposite of what the real goal should be. The real goal is to get back to a natural state, to feel healthy, joyful and alive once again. We believe that this can be achieved only with proper diet (whole foods) and high-quality amino-acid supplementation.
While this might not be possible for people with severe depression, a nutritional supplementation may be the first means of action in most cases. The brain demands a nourishing environment where it can restore health in a natural way.
According to the official website, Deplin works by addressing the imbalance in the main neurotransmitters in the brain, but it does so use artificial means. For example, most antidepressants do this by blocking the reabsorption of neurotransmitters, allowing the brain to have greater use of available neurotransmitters. The formulation acts by increasing the requirement for L-methyl folate (the active form of folate) in the brain, which facilitates the synthesis of Serotonin, Dopamine, and Norepinephrine, also known as “mood neurotransmitters.” These neurotransmitters have been associated with mood-regulating effects and maintenance of emotional balance.
Pamlab claims their product works through a natural process in the brain to regulate all three monoamine neurotransmitters associated with mood by providing adequate requirements for folate. The formula is described as a high-quality source for the single bio-available form of Folate able to cross the blood-brain barrier (BBB). This may not look like much, but it is essential for us in evaluating formula’s effectiveness as substances that are unable to cross the BBB are virtually useless to the brain.
It is important to note that Deplin is claimed to be a relatively fast acting drug. Patients should see the first improvements after 1 to 2 weeks of treatment, but the full effects are likely to occur after regular use for at least 4 to 6 weeks. These improvements consist in increased motivation, increased initiative, and improved mood and social skills.
Patients suffering from high blood pressure, bipolar disease or patients who are hypersensitive to any of Deplin’s ingredients are advised to speak to a doctor before use. It is known that Deplin can dramatically alter blood pressure levels and thus caution in using the product is recommended.
Our online research has also revealed certain complaints from patients reporting sleepless nights and vivid dreams. Deplin side effects may also include a spectrum of allergic reactions. We advise all those who are thinking about using the formula to investigate its potential harmful reactions and drug interactions further before making a purchase. Deplin dosage depends on the patient’s medical condition and response to treatment, which should be supervised by a healthcare provider.
Deplin’s price will vary based on concentration (7.5 mg or 15 mg). Regardless of the strength, Deplin is very expensive, and it is available for purchase with prescription only. While there are no online retailers for this product, there are several websites offering coupons and discounts for those who buy Deplin from their partners.
It is very likely that some patients will not be able to afford the cost of the treatment. In this case, we recommend you to address the issue to your doctor. He may be able to come up with some alternative treatments to replace Deplin.
Please take into consideration that this product is recommended for severe depression only. If you are diagnosed with mild to moderate depression, anxiety or panic attacks, you should focus on more proper treatments.
Does Deplin Work?
Deplin has received mixed reviews on the internet. Some consumers appear to be satisfied with the product, while others are reporting poor results, unwanted side effects, and even an increased level of depression after the treatment.
Additionally, this supplement is extremely expensive, and the manufacturer does not offer a free trial sample for those interested in starting treatment with Deplin. However, such samples might be provided by your medical doctor (if he believes they are necessary).
We also recommend patients to consult with their physician before taking this supplement. He may be able to offer you cheaper and safer alternatives. Deplin may be appealing to those who suffer from severe depression, but a nutritional supplementation may be the first means of action in most cases.