UPDATED 05/03/2016

Zoloft Review
Zoloft Review

PUBLISHED: 03/07/2012 by BR Technical
Editor's Review: 2.1/5.0
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Zoloft is one of the many trade names under which Sertraline is marketed, perhaps the most popular on the market. The manufacturing company, Pfizer, is a renowned multinational pharmaceutical company, based in New York City, U.S.A.

The drug is marketed as a treatment for conditions such as depression, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder. It is also used for treating premenstrual dysphoric disorder (PMDD) and social anxiety disorder. The manufacturer claims the effectiveness of the drug for each condition was demonstrated in clinical studies (placebo-controlled studies in adult outpatients).

Zoloft is a prescription drug and is associated with a series of serious side effects. It is advised that, before going under treatment, patients inform their healthcare providers about any other medicines they are taking (prescription and non-prescription), vitamins, and herbal supplements. The drug may interact with them, and thus may not work as well or may cause serious side effects.

Zoloft Ingredients

Zoloft contains the active ingredient Sertraline hydrochloride and other inactive ingredients: dibasic calcium phosphate dihydrate, colorants, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide.

Product Features

Zoloft should be administered once daily, either in the morning or evening. Depending on the condition which is intended to treat and the treatment stage, the daily dose may increase from 25 mg/day to 200 mg/day. Therefore a month’s supply may greatly vary from one patient to another.

There are serious side effects associated with the product: erectile dysfunctions, dry mouth, increased sweating, somnolence, dizziness, insomnia, nausea, diarrhea and headache. Zoloft is a prescription medicine, approved by the FDA.
According to the company, for each condition treated by the drug, clinical tests have been conducted to prove its effectiveness. For safety purposes, a complete doctor’s evaluation should be made before going under treatment.

Special warnings refer to depression worsening signs, the emergence of suicidal ideation and behavior whether or unusual changes in behavior whether or not the patient is under antidepressant medications. These risks may persist until significant remission occurs.

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Advantages

  • Excellent reputation of the manufacturer
  • Clinically tested effectiveness
  • FDA approved

Disadvantages

  • Serious potential side effects
  • Long list of precautions, warnings and medication interaction
  • High price

Conclusion

Zoloft contains Sertraline, an active ingredient which belongs to the selective Serotonin reuptake inhibitors (SSRIs) class of drugs. Sertraline blocks the uptake of the serotonin neurotransmitter in the human brain. Balancing the Serotonin levels leads to eliminating feelings of irritability, insomnia and lack of rational emotion, commonly associated with low levels of serotonin.

The manufacturer mentions clinical trials to prove the effectiveness of the drug in several anxiety and depression related conditions. Criticism towards the product refers to its long list of serious side effects. However, these risks are generally associated to antidepressant medication.

The drug is extremely popular and consumer reviews are generally favorable, most of them reporting an increased quality of life after using the product. Close monitoring is recommended for patients throughout treatment and in case of discontinuing treatment.

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Zoloft ReviewBR Technical22016-05-03 12:09:31
Zoloft Review
4.67 out of 5 based on 6 user ratings
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1 User Reviews about Zoloft
  1. 1

    What is the dosage limit for a female patient at age 64 years? I am now taking 200mg, 2xdaily. Is it dangerous to stop taking it. We have tried so many different types of antidepressions for me. But I. Just have a lot of allergic reactions. I am puzzled as to what I could take instead of the Zoloft.