Vasopressin is a hormone responsible for regulating the retention of water and for balancing the glucose and salts levels in the body, also known as the anti-diuretic hormone (ADH). Vasopressin controls blood pressure, raising it by narrowing (constricting) the blood vessels.
It is naturally synthesized in the brain (the hypothalamus) and stored in the pituitary gland, from where it is released into the bloodstream when needed.
The hormone can also be artificially synthesized in which case it is known as 8-Arginine Vasopressin. It is available as a generic product in the form of aqueous solutions or in the form of synthetic analogues (Desmopressin, Terlipressin). The synthetic analogues are commercialized under different trade names, like Minirin by Ferring, Stimate by CSL Behring or Variquel by IS Pharmaceuticals.
Vasopressin Injection USP is produced by Sandoz International, a worldwide renowned manufacturer, with a history of more than 120 years in the market for pharmaceutical drugs.
Vasopressin Injection USP includes the following active ingredient: Vasopressin (8-L-Arginine).
Vasopressin is a prescription drug and is usually administrated as an injection under the skin or into a muscle in a clinic or hospital setting. It has two main roles: it helps the kidney to conserve water and, in high concentrations, constricts the arterial blood vessels (increasing blood pressure).
Medical council is always required before administrating Vasopressin. This is a prescription drug and should be taken under strict doctor’s order.
The list of counter indications is rather extended and includes chronic kidney conditions, asthma, congestive heart failure or a history of seizures. Precautions refer to pregnant or breast-feeding women or women who plan on becoming pregnant.
Side effects reported include, but are not limited to: cardiovascular side effects (cardiac arrest, angina, increased blood pressure), dermatological side effects (sweating, cutaneous necrosis, especially at the site of administration), gastrointestinal side effects (vomiting, abdominal cramps, diarrhea), renal side effects (such as acute renal failure); nervous system related side effects (headache, tremor) and respiratory side effects (pulmonary edema, bronchial constriction).
Vasopressin is usually given as needed every 3 to 4 hours.
- Good reputation of the manufacturer
- Proven effectiveness
- Long list of side effects, precautions an warnings
- Relatively high cost of treatment
Using Vasopressin requires a doctor’s prescription and the drug can be administrated only by specialized personnel in a clinic or hospital setting.
Clinical studies have shown Vasopressin to be effective in cardiac arrests, septic shocks, diabetes insipidus or hypotension. Even so, the product is known to have a wide range of adverse effects. Therefore electrocardiograms and other tests are recommended periodically during therapy.
Vasopressin is a prescription drug, so you must inform your doctor of any health conditions, potential drug allergies or drugs you are already using, before you are prescribed the right dosages for your treatment with Vasopressin or analogues.