UPDATED 05/07/2016

TwinLab Acetyl L-Carnitine Review
TwinLab Acetyl L-Carnitine Review

PUBLISHED: 09/30/2012 by brreader
Editor's Review: 3.2/5.0
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TwinLab Acetyl L-Carnitine

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TwinLab Acetyl L-Carnitine is a dietary supplement offered as a support to enhance cognitive function as well as physical performance. The manufacturer is TwinLab, a company founded in the late ‘60’s by David Blechman to produce and market a liquid protein supplement. Later, the company extended their range of products to vitamins, minerals and herbal supplements, sports nutrition supplements and teas.

The formula is based on the acetyl ester of L-carnitine, a precursor of the essential neurotransmitter called Acetylcholine (ACL). Besides the benefits on cognitive function, ACL is also essential to energy production processes. It helps transport long-chain fatty acids into the mitochondria of the cell, responsible for the energy production and beta-oxidation.

TwinLab Acetyl L-Carnitine is advertised as a product well tolerated by allergic individuals also lacking the harmful substances commonly used in this kind of products (such as preservatives, colorings, coating, sugars and salts).

TwinLab Acetyl L-Carnitine Ingredients

TwinLab Acetyl L-Carnitine formula contains the following ingredients: Acetyl L-Carnitine, Cellulose, Gelatin, Purified Water, Calcium Stearate, MCT, and Silica.

Product Features

TwinLab Acetyl L-Carnitine is an amino-acid based formulation. The formula is based on a single active ingredient, specifically Acetyl L-Carnitine which is the acetylated form of L-Carnitine.

ACL is the precursor of the neurotransmitter Acetylcholine, an important neurotransmitter, meaning a chemical responsible for the transmission of information between brain cells by transferring nerve signals from one nerve to another. It is considered essential for the stimulation of short-term memory, attention while also promoting REM sleep.

Another important role of ACL is to carry fatty acids from the cytosol – the main body of the cell into the mitochondria, the energy-producing furnaces within cells so that fats can be oxidized for energy.

Consumers have found TwinLab Acetyl L-Carnitine to be effective in increasing energy levels (recommending it as excellent in assisting during workout programs) and increasing mental alertness.

The formula is recommended as a dietary supplement for adults in doses of 1-4 capsules daily or as directed by the healthcare professional. There is however no evidence of clinical studies involving TwinLab’s formula. The manufacturer mentions no side effects or drug interactions. However, Acetyl-L-carnitine might cause stomach upset, nausea, vomiting and restlessness, as well as a “fishy” odor of the urine, breath and sweat. Also, there is concern that it may slow blood clotting speed and hence interact with medication used to slow blood clotting.

Sale Price: $54.95

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Store: Amazon

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  • Researched active ingredient
  • Reputable manufacturer
  • Generally positive reviews from consumers
  • Moderate price for a month’s supply (under $30)


  • Insufficient clinical evidence of the active ingredient’s benefits
  • Potential side effects and drug interactions of Acetyl-L-Carnitine


TwinLab Acetyl L-Carnitine is advertised as a high quality source of Acetyl L-Carnitine, designed to provide its users with the necessary support for maintaining a healthy cognitive function and for increasing overall energy and physical performance.

The manufacturer is an experienced international company and consumer reviews report that TwinLab Acetyl L-Carnitine works to deliver the benefits mentioned by the advertising. This is why we may assume the formula works for some consumers. However, each patient is different and some may not experience these benefits or experience them with a lower intensity.

However TwinLab Acetyl L-Carnitine, like all dietary supplements, has not been evaluated by the FDA, and there is no scientific evidence to support its effectiveness. Before considering taking any unapproved nutritional supplement you should always consult a healthcare professional.

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TwinLab Acetyl L-Carnitine Reviewbrreader32016-05-07 12:09:31
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