UPDATED 05/05/2016

Treximet Review
Treximet Review

PUBLISHED: 05/18/2012 by BR Publishing
Editor's Review: 2.3/5.0
Product Star Rating 10yrs or More
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Treximet is a product designed to mediate vasoconstriction, vasculature of human dura-mater and inhibit the synthesis of inflammatory mediators in order to obtain relief of migraine headache.

The manufacturer is the international worldwide renowned pharmaceutical company GlaxoSmithKline (headquartered in UK) which produces a wide range of medicinal products which treat major diseases like diabetes, cardiovascular, mental health, asthma, infections and digestive conditions.

This supplement is advertised as a migraine treatment based on 2 active ingredients, sumatriptan and naproxen which contribute to the relief of migraine through pharmacologically different mechanisms of action. Treximet has been the subject of double-blind randomized trials and has proven effective in reducing headache severity from moderate or severe to mild or no pain.

Please note that Treximet is a form of prescription medication and should only be used under strict doctor’s orders.

Treximet Ingredients

Treximet contains the following ingredients: sumatriptan succinate, naproxen sodium, croscarmellose sodium, dextrose monohydrate, dibasic calcium phosphate, FD&C Blue No. 2, lecithin, magnesium stearate, maltodextrin, microcrystalline cellulose, povidone, sodium bicarbonate, sodium carboxymethylcellulose, talc, and titanium dioxide.

Product Features

Treximet is a prescription drug product designed to fight acute migraine attacks in adults.

Sumatriptan is one of the two active ingredients in this product which mediates vasoconstriction and has been proven, through clinical trials on animals, to activate the trigeminal nerve innervating cranial blood vessels. These tests conclusions are that Sumatriptan may contribute to the antimigrainous effect in humans.

Naproxen sodium is a Nonsteroidal Anti-inflammatory Drug (or NSAID) with known analgesic properties. Although its exact mechanism of action is not fully understood, researchers believe it works by inhibiting the synthesis of inflammatory mediators, which may cause migraine pain.

There are several severe side-effects mentioned by the manufacturer, most important being cardiovascular conditions related (may increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal), gastrointestinal related (the NSAID ingredient causes increased risk of serious gastrointestinal adverse events like ulceration, bleeding and perforation of the stomach or intestines, which can be fatal).

The recommended dose of Treximet is one tablet whenever migraine appears.

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  • Clinically researched product
  • Reputable, international manufacturing company
  • Approved by the FDA.


  • Large number of severe side-effects (like in most cases of prescription medication)
  • Few consumer reviews available
  • Long list of precautions.


Treximet is a medically researched prescription anti-migraine drug manufactured by GlaxoSmithKline, an international leader in medical industry.

The formula is based on 2 active ingredients and underwent clinical trials with good results regarding its effectiveness. It is a product approved by the FDA but has many serious (some of which can even prove fatal) side-effects and drug interactions warnings.

The manufacturer recommends that consumers use Treximet under a healthcare professional’s supervision and take immediate measures in case of any listed side effect occurs. Special precautions are issued for pregnant women, as test results on animals have revealed decrease of fetal bodyweight, increase of embryo fetal death and malformation occurrence.

Pain Management,Review Box – Show On PageTreximet Review
Treximet ReviewBR Publishing2.252016-05-05 12:09:31
Treximet Review
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