UPDATED 05/12/2016

Phrenilin Review
Phrenilin Review

PUBLISHED: 01/29/2014 by brreader
Editor's Review: 3.3/5.0
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Phrenilin is a prescription medication created as a treatment for tension headache. The formula is developed by Valeant Pharmaceuticals International a manufacturer of more than 80 drugs in the United States. The company markets and distributes their tis formulations internationally in the following geographic regions: USA, Canada, Latin America, Australia, and Europe (Central and Eastern).They claim to focus on the particular needs of each country and provide unique products for each of them, in the form of prescription drugs, branded generics, and over-the counter formulations.

Phrenilin is classified as an analgesic, and is based on the therapeutic effects of two active substances: Butalbital and Acetaminophen. This type of medication has been associated with several potentially dangerous side effects, including dependency and abuse (Butalbital is a habit-forming substance) and liver failure that may lead to death (associated with the use of Acetaminophen doses higher than 4,000 mg). Because of these high risks, the drug is not recommended for people suffering from conditions like severe impairment of the renal or liver function, people with acute abdominal conditions, or those with known allergies to any of the active substances.

The drug may also impair one’s mental and/or physical abilities and it should not be administered while driving or operating heavy machinery.

Phrenilin Ingredients

Phrenilin contains the following ingredients: Butalbital, Acetaminophen, Alginic acid, corn starch, D&C Red No. 27 – Aluminum Lake, FD&C Blue No. 1 – Aluminum Lake, gelatin, magnesium stearate, microcrystalline cellulose, and pregelatinized starch.

Product Features

One of Phrenilin’s key ingredients is Butalbital. This is a substance form the Barbiturate class of compound and, as a pharmaceutical ingredient, is usually used in combination with other substances designed to reduce pain. The use of this substance against tension headache has been approved, but it is not recommended as a first-line treatment due to its numerous side effects. This chemical was reported to cause severe reactions like dependence and addiction to Butalbital, increased frequency of the headaches, and severe judgment impairment. Common side effects are nausea, sedation, drowsiness and dizziness, memory loss, and digestive problems. Mixing this substance with alcohol may lead to intoxication, respiratory depression and liver toxicity. Suicide or accidental death may also occur when mixing such a drug with other narcotics.

Acetaminophen is the US and Japanese adopted name for Paracetamol. It is classified as a mild analgesic recommended as a pain reliever in minor aches, including headache. However, the substance is also used in combination with opioid analgesics in which cases it may be recommended for the treatment of more severe conditions. Acetaminophen is generally considered safe when used in the recommended dosage, but may become fatal if these doses are exceeded, even by small amounts. The main worry with Acetaminophen overdose is liver failure, accentuated by the use of alcohol.

The substance is not included in the Nonsteroidal anti-inflammatory class of drugs. Although it has been shown to have similar analgesic properties as NSAIDs, its anti-inflammatory effects are considerably reduced compared to these substances.
While this substance is considered likely safe for short-term or occasional use, there are a few severe side effects that should concern and therefore be taken into consideration by consumers. Aside from the liver damage, the substance may also increase the risk of blood cancer and or cause severe skin reactions (the Steve-Johnson syndrome).

Phrenilin side effects include similar reactions to those caused by the active ingredients: drowsiness, shortness of breath, nausea, vomiting, intoxication, sedation, and dizziness. Phrenilin reviews are relatively reduced in number, but seem to support the benefits of the drug in reducing headache.
The suggested dose is 1-2 tablets every four hours without exceeding a daily dose of 6 tablets.

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  • The active substances are clinically researched
  • The product is only available by prescription, so there is a reduced risk of improper administration (usually associated with self- administration of drugs)
  • The manufacturer is a reputable company, with an international activity


  • The manufacturer does not specify any information about such a product on the official webpage
  • The formula may result in severe unwanted side effects
  • Special attention is recommended to doctors who prescribe such medication (particularly to the medical history of the patient)- improper use by certain categories of people may be fatal.


Phrenilin delivers 50 mg of Butalbital and 325 mg of Acetaminophen in a serving. The product is classified as an analgesic and is not subject to the Controlled Substances Act. There are many concerns associated with this prescription drug which shouldn’t be taken lightly by the physicians or by their patients.

The formula is also available in the form of Phrenilin Forte that features a double amount of Acetaminophen. It does not contain any caffeine. The medication should be kept out of the reach of children to prevent any accidents. Safety and effectiveness in children under the age of 12 has not been evaluated. There is also a great risk for serious reactions in infants and fetuses, so pregnant and breastfeeding women are highly advised to refrain from using any product based on these substances.
Phrenilin overdose may be potentially lethal.

Pain Management,Review Box – Show On PagePhrenilin Review
Phrenilin Reviewbrreader3.252016-05-12 12:09:31
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