UPDATED 04/27/2016

Phenibut Review
Phenibut Review

PUBLISHED: 01/29/2014 by BR Moderator
Editor's Review: 2.9/5.0
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Phenibut is a neuropsychotropic dietary supplement recommended as an anxyolitic. The formula is offered by an American supplier of nutritional formulations called Nutraceutics RX. Official information about this manufacturer or its activity is not accessible to us. This is why it is very hard to assess the company’s compliance with FDA and GMP regulations or the quality of their range of supplements.

This formula is based on a single active ingredient similar to the inhibitory neurotransmitter GABA, but it is claimed as more effective in crossing the blood brain barrier. In fact, there are many concerns (and research is ongoing in this direction) about the actual amount of supplemental GABA that actually penetrates the blood-brain barrier.

The supplement is advertised to act as a GABA-mimetic, primarily at GABA(B) and also stimulates Dopamine receptors. It is designed for adults affected by the numerous daily stress factors by reducing their negative effect while increasing focus and concentration capacities. The key ingredient is Phenibut, also known as beta-phenyl-gamma-aminobutyric acid, discovered in the 1960’s in Russia and used initially to alleviate symptoms of tension, anxiety and fear, post-traumatic stress, improve sleep and symptoms of conditions characterized by depression or asthenia.

Unfortunately, there is not a lot of information available about Nutraceutics RX Phenibut’s action mechanism or the associated unwanted effects. An official source that provides this kind of information could not be found.

Phenibut Ingredients

Phenibut contains the following ingredients: Phenibut, gelatin, and rice flower.

Product Features

The active substance of Phenibut has been used as an ingredient of anti-anxiety products for more than 60 years. The substance’s benefits were first noticed by conducting in vitro tests on animals. Its effects have been compared to those of diazepam and Piracetam. Today, the number of scientific references is much higher (over 300 hundred). This compound is believed to increase GABA levels in the brain due to its ability to easily penetrate the blood brain barrier. Gama aminobutyric acid is a natural chemical produced in the human brain shown to be responsible for the brain’s response to stress, promote lean muscle growth, relieve pain, and stabilize blood pressure. The benefits of appropriate GABA levels are reduced anxiety feelings and overall body fat, improved physical performance and other conditions. The important neurotransmitter acts as an inhibitory by blocking communication between brain cells.

The key substance in Phenibut is a beta-derivative of GABA demonstrated to have the strongest sedative effect from all derivatives of GABA. The advantages of using such a compound as opposed to GABA have been observed in clinical trials on two different levels: effectiveness and side effects (it lacks the anticonvulsant effects usually associated with the use of GABA supplements). Animal studies also support the compound’s nootropic activity, tranquilizing and anxyolitic effects. The benefits of Phenibut on sleep also seem to be of high interest, and it seems like the effects of the substance in this area are unmatched.

Phenibut side effects in humans are unknown due to lack of clinical research on humans. Excess amounts have been reported to cause dry-mouth and dizziness. Phenibut’s withdrawal symptoms are one of the main concerns with this product. These symptoms may manifest as seizures, insomnia, or increased hear rates. The recommendation is to gradually lower the doses and allow the body to readjust to the reduced doses. Phenibut recommended dosage is between 250 mg-1500mg.

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  • The active substance has been clinically studied (most of the research involves animal subjects)
  • The key ingredient has been used for decades as an anxyolitic agent with positive outcomes reported
  • The number of side effects is relatively low (as reported by consumers)


  • This manufacturer of the formula does not have an official page (essential information about the formula is lacking)
  • There are no reviews available for consulting about this specific formula
  • Phenibut withdrawal effects are considered dangerous and should be treated with seriousness.


Phenibut dietary supplement is based on the therapeutic benefits of a clinically researched substance. However, research on human subjects is still in its beginnings, so a complete list of drug interactions, side effects and other important things to consider when using this over-the counter formula has not been established.

Various manufacturers commercialize this formulation as Phenibut powder or capsules. Although both forms seem to be effective, the encapsulated form is claimed to lack the unpleasant taste of the powder. However, on the long run, the powder is the more affordable solution. As with all dietary supplement that don’t benefit of the FDA’s approval, our recommendation is to consult a healthcare practitioner before using the formula.

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Phenibut ReviewBR Moderator32016-04-27 12:09:31
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