UPDATED 05/18/2016

NeuroSAMe Review
NeuroSAMe Review

PUBLISHED: 11/01/2013 by breditor
Editor's Review: 2.6/5.0
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NeuroSAMe is a dietary supplement designed for people who suffer from depression. The company behind this product is Amen Clinics, which was founded more than 30 years ago by Dr. Amen. He has a very prestigious career, being a famous physician, psychiatrist and a well-known author. Considered one of the best researchers in the field of brain imaging, Dr. Amen has contributed to the developing of his company’s dietary supplements. However, his use of brain SPECT scans for psychiatric and neurological diagnosis of patients has generated some criticism. Amen Clinics claims to offer the most advanced nutritional help and they provide programs to help people achieve an optimal health.

According to its manufacturers, NeuroSAMe was made for depressive individuals and it is based on SAMe, which is S-Adenosyl L-Methionine, a naturally occurring metabolite found in the body that is produced from the amino-acid methionine. This nutrient is the most active methyl donor and is involved in the synthesis of the neurotransmitters serotonin, dopamine, and epinephrine, which play an important role in mood regulation and energy.

Moreover, the company claims that NeuroSAMe is superior to other products on the market due to its stability resulted from the nitrogen blister packs and maximized bioavailability by an enteric coating, as it is very sensitive to degradation from air and moisture.

NeuroSAMe Ingredients

NeuroSAMe contains the following ingredients: Vitamin B6 (Pyridoxine HCL), Folic Acid, Vitamin B12 (Cyanocobalamin), S-Adenosyl L-Methionine (as Disulfate Monotosylate), Microcrystalline cellulose, croscarmellose sodium, methacrylic acid co-polymer, colloidal silicon dioxide, magnesium stearate, triethyl citrate, stearic acid, citric acid, ascorbic acid, and riboflavin.

Product Features

As stated before, the key ingredient in NeuroSAMe is S-Adenosyl L-Methionine or SAMe. One of its many functions consist in the production of melatonin, which the sleep hormone. It is also involved in the cell membrane stabilizing phospholipids that support the proper cellular communication and are essential to brain health. Deficiencies in this metabolite are linked to depression and neurovegetative disorders. While supplements based on this element shown imprevement for symptoms of depression, it also contributes to joint inflammation and pain reduction, sleep quality, improving the liver detoxification process, suppressing appetite for those who want to lose weight and increase glutathione levels, which are very important in neuroprotection. Although SAMe has been proven to be generally safe, there is a minor risk of mania for certain individuals.

The body may produce normal or average levels of this metabolite, but aging, dietary deficiency, inflammatory states, emotional stress or genetic polymorphisms may require a higher demand. Increasing the supply of enzymes co-factors such as SAMe, magnesium or B-vitamins is thought to be a great help for enzymes deficiency, which is normally related to aging. The formula also includes Vitamins B6, B12, and folate as cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine. This dietary supplement should be taken once or twice daily, preferably on an empty stomach. It is not recommended for those who suffer from the bipolar disorder, unless under professional medical supervision.

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  • The product is stated as being unique, due to its stability in the nitrogen blister packs and maximized bio-availability by an enteric coating
  • One bottle may be enough for one month’s supply, as it contains 30 tablets
  • There are specific use directions, with smaller dosage in the beginning and increasing it after awhile


  • There are no testimonials available on the website
  • The product has not been reviewed by the FDA and it was not clinically studied
  • SAMe may produce certain side effects such as nausea, vomiting or even mild insomnia if excess doses are used


NeuroSAMe may support the reduction of depression associated symptoms, improving sleep quality, balancing brain chemistry and for overall health of the brain. The tablets are enterically coated in order to prevent its breakdown by stomach acidity and support an intact absorption in the small intestine. There are no available testimonials for this product at the moment on the manufacturer–s website and no mentioned clinical trials. This product does not contain wheat, soy, corn, yeast, milk, or gluten, which makes it suitable for those who require non-allergenic formulas. It is highly recommended you seek for medical advice prior to the administration of NeuroSAMe.

Depression Help,Review Box – Show On PageNeuroSAMe Review
NeuroSAMe Reviewbreditor2.52016-05-18 12:09:31
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