UPDATED 05/12/2016

Nature Made SAM-e Complete Review
Nature Made SAM-e Complete Review

PUBLISHED: 10/19/2012 by breditor
Editor's Review: 3.7/5.0
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Nature Made SAM-e Complete is advertised as a nutritional supplement designed to restore a healthy balanced mood and provide joint comfort by replenishing the body’s natural SAM-e supply. The formula is manufactured by Pharmavite, under the Nature Made brand.

According to the manufacturer, the formula is the number one bestselling brand of SAM-e supplement. Pharmavite is a company located in California, U.S.A, which manufactures a variety of condition specific medication and dietary supplements. The formula is part of the Nature’s Made line of products, claimed to be the first line of dietary supplements to earn a third-party quality seal of approval through the USP (United States Pharmacopeia) Verification Program.

The manufacturer mentions that Nature Made SAM-e Complete is clinically proven to help restore a healthy mood in as little as 7 to 14 days, although no evidence is brought to support this claim.

Nature Made SAM-e Complete Ingredients

Nature Made SAM-e Complete includes the following ingredients: Dibasic Calcium Phosphate, Thiamin Mononitrate, Pyridoxine Hydrochloride, d-Calcium Pantothenate, Riboflavin, Niacinamide, Cellulose Gel, Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium, Polyethylene Glycol, Folic Acid, Cyanocobalamin, and Biotin.

Product Features

Nature Made SAM-e Complete contains 400 mg SAMe (S-Adenosyl Methionine), a chemical naturally produced by the body, particularly in the liver. SAM-e’s medical applicability derives from its role in the secretion and metabolism of key neurotransmitters Melatonin, Serotonin, and Dopamine. There is evidence that SAM-e may be effective in managing symptoms of mood disorders such as depression and dystimia. Additionally, research has shown that SAM-e may be useful in treating anxiety disorders including generalized anxiety disorder, obsessive-compulsive disorder and depressed mood.

SAMe has also been studied in relation to Alzheimer’s disease and dementia, as severely low levels of SAM-e have been found in all brain regions an in the cerebrospinal fluid of Alzheimer’s disease patients examined. Additional research is however necessary to establish a relation between the two factors. There is also increased interest in studying SAM-e for pain disorders such as fibromyalgia, chronic fatigue syndrome and migraine headache and attention disorders such as ADHD.

SAMe seems to be well tolerated by most people on the short term; however it can cause gas, vomiting, dry mouth, headache, diarrhea, constipation, mild insomnia, dizziness and nervousness, especially at higher doses. It can make some people with depression feel anxious. Long term side effects of SAM-e are currently unknown. There is serious concern about its interaction with depression drugs, MAO Inhibitors, and other drugs that may increase Serotonin in the brain.

The manufacturer recommends taking 1 tablet of Nature Made SAM-e Complete daily 30 minutes before a meal. The manufacturer mentions a satisfaction guarantee policy, but gives no further details. Consumer testimonials generally claim the formula is effective, while reporting certain side effects such as stomach cramps and pains. The manufacturer recommends avoiding use when taking St. John’s Wort and MAO Inhibitors.

Sale Price: $51.29

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  • Money Back Guarantee available, although details will have to be obtained through an inquiry with the manufacturer;
  • The supplement is free of artificial flavors, preservatives, yeast, and gluten;
  • Generally positive consumer reviews.


  • Several serious potential drug interactions and side effects;
  • Relatively expensive product (a month’s supply may cost as much as $50 if no promotions or discounts are applied).


Nature Made SAM-e Complete is based on a single active ingredient, SAM-e, a substance important to regulating mood. SAM-e is also able to offer liver protection, joint function, and liver function support. There is a large number of consumer reviews referring to the formula, generally reporting it to be effective in restoring a balanced mood and alleviating symptoms of depression and anxiety  Still, you should be aware that SAM-e may interact with a number of anti-depressants, especially MAO inhibitors. This is particularly why we highly recommend that you discuss all details with a healthcare provider before using the dietary supplement.

Boost Mood,Review Box – Show On PageNature Made SAM-e Complete Review
Nature Made SAM-e Complete Reviewbreditor3.52016-05-12 12:09:31
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