UPDATED 04/25/2016

Metanx Review
Metanx Review

PUBLISHED: 06/06/2012 by brreader
Editor's Review: 3.4/5.0
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Metanx is a form of prescription medication for people suffering of diabetic neuropathy. It is developed by Pamlab, a company that deals with natural personalized medicine. The manufacturer is US-based and has a large selection of products designed to alleviate symptoms or conditions, and have received a number of accreditations and awards for their supplements.

Diabetic neuropathy is a condition that affects the peripheral nerves, which can have consequences on all the organs. It produces a large amount of discomfort to people that suffer from this condition, causing them to experience numbness, tingling of the extremities, speech impairment, issues with coordination, drooping of eyes and mouth, and muscle weakness. Metanx claims to ameliorate some of these symptoms, through the activated B-vitamin complex that it contains.

Generic Metanx may be available within pharmacies, however it seems that it is difficult to come across. It is best you ask a specialized opinion prior to making a purchase, given that certain side effects of Metanx or the generic version may arise.

Metanx Ingredients

Metanx contains the following ingredients: L-methylfolate Calcium (as Metafolin), Pyridoxal 5′-phosphate, and Methylcobalamin.

Product Features

The product is composed of a formulation of activated B-vitamins, designed to alleviate the symptoms and consequences of diabetic neuropathy. The ingredients, L-methylfolate Calcium, Pyridoxal 5′-phosphate and Methylcobalamin are actually activated forms of Folic Acid (vitamin B9), B6 and B12. The use of activated natural minerals is considered very beneficial for the human body, seeing as it’s more easily absorbed by the organism in order to be put to use.

All three active ingredients have been successfully used in the treatment of diabetic neuropathy, as well as other conditions: L-methylfolate Calcium is useful in prenatal care, treating depression and dementia; Pyridoxal 5′-phosphate is used to facilitate neuro-transmission and increase cognition, and Methylcobalamin is the first-line treatment of amyotrophic lateral sclerosis.

The individual ingredients being used in treatment of the condition does not provide enough credibility to the medication on its own. That’s why the producers of this formula offer information regarding clinical trials and even medical samples. While this service is only offered to medical professionals, it greatly increases the credibility of the medication.

According to the manufacturer, the supplement is a very safe product, cause virtually no side effects and being easy to administer: a daily dose of two tablets should be sufficient to help people with their condition. Side effects include mild breath odor and stomach problems, while more rare but more severe side effects of Metanx may include rash, hives, tingling, difficulty breathing and swelling of the tongue. Numerous Metanx alternatives exist, that contain all or part of the key active ingredients and which claim similar health benefits.

The daily dose for Metanx tablets or capsules should be recommended by a doctor, whereas the daily dosage should not be exceeded.

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  • The supplement can be taken by vegetarians and vegans as well
  • Product claims are realistic and well-documented
  • Metanx reviews from consumers are generally positive and report high levels of efficacy
  • The manufacturer provides much relevant information for this medication
  • No artificial stimulants
  • Both Metanx tablets and capsules are available for purchase
  • Metanx alternatives are available to consumers, in the form of exact formulas or similar ones


  • Product is only available via prescription
  • It is an expensive product: a supply for three months can cost up to $150
  • Product is not available for online purchase


Diabetic neuropathy can greatly decrease life quality for people who suffer from this condition. Pamlab tries making life easier for these people, with a well-researched, medically-attested product. Metanx reviews from people that have already tried it place it as highly effective in relieving diabetic neuropathy symptoms. Some people have also used it as a cognitive booster, increasing their memory and reducing their mental fatigue.

Unfortunately, the product is considered very expensive by most consumers, which often pushes customers to buy generic Metanx, non-prescription supplements or other different formulations which promise similar benefits. Both of these alternatives could prove less effective than Metanx, although there are some alternatives to this product that are reported to perform just as well.

If you have been prescribed Metanx, it is highly recommended you respect the indications provided by your doctor. Do not go above or below the prescribed dose, and keep in mind that combining specialized medication with a healthy lifestyle can greatly increase the quality of your life.

Other Problems,Review Box – Show On PageMetanx Review
Metanx Reviewbrreader2.752016-04-25 12:09:31
Metanx Review
4.25 out of 5 based on 12 user ratings
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8 User Reviews about Metanx
  1. 1

    Leonard Strider

    I have taken Metanx for 18 months ,, I still have the burning in my feet. I have seen NO IMPROVEMENT .. I have stopped taking Metanx My rating ? >> for me >> it does not work. I am NOT a diabetic >> My Doctor knows that I have stopped taking Metanx>

  2. 2

    I used Metanx for 2 months, as prescribed by my doctor and I’m very pleased with the results. I’m feeling way better than two months ago.

  3. 3

    Kenneth V. Rhea

    I have neuropathy in my feet and legs and maybe even in my back. Would metanx cure this condition. I took two months treatment at New Promise Nueropathy Care Center but did not improve. I am now looking for some other treatment source. Can some one help me?

  4. 4

    I have taken Metanx for about 3 weeks. I’ve noticed that it is making me sick to my stomach in the mornings. Is this suppose to be taken on a lull stomach?

  5. 6

    I was told to take 2 tablets a day. I have severe
    neuropathy in both feet for years. Would it be
    alright to take 3 or 4 tablets aday?
    Thanks, Rob

    • 7

      Hi Rob,

      Metanx is a form of prescription medicine and in this case we cannot offer dosage recommendations. The only one entitled to such recommendations is your doctor. Our advice is to go and talk to him about these symptoms and he can decide if your dose is too high (or too low) or if another treatment is required in your case.

      BR Editor

    • 8

      I am also a big fan of Metanx. I recommend it to All of our patients with any type of nerve problems. Besides containing “healthy ” support for nerve function, it lowers the levels of homocytstien, an aminoacid that can be harmful to circulation. I see a lot of cardiologist now are recommending it as an adjunctive treatment for CAD. William : due to the nature of the product being a B 6, b12, folic acid combo, this is a relatively safe, harmless product as B vitamins are water soluable and excreted in the urine. They are not stored in the liver like A,D,E,&K. I think you have nothing to loose but much to gain if it works. I have diabetic neuropathy and take 2 daily. You may want to start with one tab and try it for 2 weeks if no improvement up the dosage to 2 daily. I have heard some docs speak that some patients need up to 4 a day. You will need a prescription to get it though. I am so glad I found this post.
      My Doctor just prescribed Metanx for me today for my neuropathy.
      I have been searching for something to help me get off the lyrica because the lyrica is causing so much weight gain for me.
      This post makes me feel so much better. I am glad it is working for you and I so hope it does for me also. I have been on Metanx for 6 weeks 2 a day and the results have been overwhelming. I have not only cut my pain meds back to as needed, but I have stopped the dreadful lyrica. Lyrica was making me vomit and I was unable to drive. Metanx has been a life saver. Stick with it. Hope you too feel better. I always recommend two pills daily and have not had any patients report nausea. Somnolence (drowsiness) is reported in the literature but is also a side effect that I’ve never heard reported from any of my patients in all the years of prescribed Metanx or it’s predecessor Foltx.
      However, any medication can cause any reaction in any patient.

      Metanx can take up to 4 months to provide benefits, though in my practice the majority of my patients see SOME relief or benefits within a few weeks. I’m glad to hear that you’ve found a doctor that at least seems thorough, though I’m sorry to learn that you’ve also been diagnosed with diabetes. I’m sure that’s another diagnosis you didn’t need to have added to your list.
      Although it certainly won’t ‘cure’ all your symptoms, I am a VERY strong proponent of the use of Metanx for my patients, especially those who are diabetic and those with any symptoms of neuropathy.
      The patients who I have prescribed Metanx for have overall reported tremendous relief of their symptoms. Metanx is basically a prescription form of B vitamins, but even those that were previously taking B complex vitamins are often helped by Metanx. FYI…here’s what the Metanx website says: Metanx® helps the blood vessels to produce a natural vasodilator called nitric oxide. As a result, blood flow increases in the vessels that carry important nutrients and oxygen to the nerves.9 Metanx® also works to assist in nerve functions including production of the myelin sheath, a fatty substance that protects the nerve fibers. Note: The only side effects that my patients have reported have been a temporary/transient loosening of their bowels, which was a welcome side effect for some of my elderly patients! LOL… Although I agree with your doctor that it may take a while to obtain relief with Metanx, I do not agree that you must wait 6 months. Some of my patients obtain some level of relief with 2 weeks, but the overwhelming majority see positive results within 2 months or sooner.
      In my experience, if a patient has not obtained significant relief within 3 months, he/she will not see any significant benefits down the line. First of all, if there is any injury to the nerve, the Lyrica will not ‘help’ that injury. Lyrica simply treats the symptoms of nerve disorders such as pain, burning, etc.,but really does nothing to ‘treat’ the underlying problem.
      If there is an injury to the nerve or damage to the nerve, your doctor may want to consider treatment with a complex of B vitamins or the use of a medication called Metanx. This is usually used for patients with diabetic neuropathy, but I often use this medication with patients with various nerve related symptoms that aren’t diabetic, with significant success. May God Bless you all are my prayers…