UPDATED 05/16/2016

Doctor’s Best SAMe Review
Doctor’s Best SAMe Review

PUBLISHED: 10/08/2012 by BR Moderator
Editor's Review: 3.3/5.0
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Doctor’s Best SAMe

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Doctor’s Best SAMe is advertised as a science based nutritional supplement designed to enhance mood and neural function. The supplement is manufactured by Doctor’s Best. The company mentions joint comfort and mobility and liver and detoxification support as side benefits of the formula. Doctor’s Best is located in California, United States and was founded in 1990. The company offers therapeutic nutrition solutions based on traditional medicinal knowledge and current scientific research. The product portfolio includes products which target a variety of ailment claims, including brain and memory, mood enhancement or sleep and relaxation. Doctor’s Best SAMe is recommended exclusively to adults. People diagnosed with bipolar disorder (or manic depression) are advised to avoid SAMe supplementation, as it may aggravate the manic phase.

Doctor’s Best SAMe Ingredients

Doctor’s Best SAMe includes the following ingredients: S-Adenosyl Methione, cellulose gel, Methacrylic Acid Copolymer, Compritol 888ATO, Talc, Triethyl Citrate, Titanium Dioxide, Magnesium Stearate, Manitol, Glycerol Palmitostearate, Silica, Medium Chain Triglycerides, Sodium Starch Glycolate, and Iron Oxide.

Product Features

Doctor’s Best SAMe contains 200 mg SAMe (S-Adenosyl Methionine), a compound naturally produced by the body and known as one of the most active methyl donors. SAMe has been extensively researched over the past years and evidence shows it plays an important role in the immune system, cell membranes health and liver function. Additionally, research revealed it participates in the secretion and metabolism of key neurotransmitters such as Serotonin, Melatonin and Dopamine. By doing so, SAMe may potentially be effective in health areas that these neurotransmitters are known to regulate. For instance, SAMe is tested for benefits against depression, anxiety, obsessive-compulsive disorder or panic, known to be caused by Serotonin deficiencies. Similarly, it may positively impact memory and learning capacity, aging, sleep, aggression mood and motivation. The largest amounts of SAMe are produced and active in the liver. This is why low levels may indicate liver dysfunction and lead to liver damage. Supplementation is generally used to reduce inflammation and dysfunction of the liver. Long term side effects of SAMe are currently unknown, however high doses may lead to anxiety, restlessness and even insomnia. Special precautions are recommended to people suffering from bipolar disorder. The manufacturer recommends taking 1 tablet daily away from food, although an exact daily dose has not been established yet. Consumer reviews of Doctor’s Best SAMe are mixed.

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  • SAMe has been extensively researched and proven effective in some areas;
  • Affordable (2 month’s supply costs approximately $20);
  • Does not contain milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, or preservatives.


  • Not sufficient data on long-term supplementation effects;
  • Contraindicated for people with Bipolar Disorder;
  • Mixed consumer reviews.


Doctor’s Best SAMe contains a single active ingredient, SAMe. Research revealed that this naturally occurring compound is able to offer liver protection, joint function support and mood enhancement. While large scale research is required to confirm some of SAMe’s benefits, it can be argued that Doctor’s Best SAMe will work to deliver on its advertised benefits at least for some consumers. Consumer reviews received are mixed: while some consumers report almost immediate results, others say this is nothing more than a placebo. All things considered, we believe you should discuss all details with a healthcare provider if you decide to use Doctor’s Best SAMe.

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Doctor’s Best SAMe ReviewBR Moderator3.252016-05-16 12:09:31
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1 User Reviews about Doctor’s Best SAMe
  1. 1

    Thelma Wright

    I began taking Doctors Best SAMe a few ago. Prescription antidepressants can’t compare with it and I have tried more than a few, after losing my husband to cancer. I personally recommend taking it taken around noon, on a empty stomach. I feel it better absorbs that way. I wish it weren’t this pricey, but it’s still the best on the market for me.