UPDATED 05/14/2016

Calm-PRT Review
Calm-PRT Review

PUBLISHED: 01/08/2013 by breditor
Editor's Review: 2.7/5.0
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Calm-PRT is a brain supplement advertised to assist with stress reduction, promote sleep and reduce excitability. The manufacturing company NeuroScience claims the formula works by restoring communication within the hypothalamic-pituitary-adrenal (HPA) axis, hence reduce Cortisol and catecholamines release as a response to stress.

NeuroScience is company founded in 1999 and headquartered in the United States. The company specializes in laboratory tests and clinical tools that target the neurological, endocrine and immune systems. Additionally, a dedicated line of products targeting the spectrum of neurotransmitter imbalances has been developed and currently includes more than 50 different products. The company’s official website is comprehensive and offers extensive information on various health conditions and company products.

Because Calm-PRT helps restore a healthy HPA axis, the product is especially suited for patients with elevated levels of epinephrine, Norepinephrine, and Cortisol, but can also be useful for anyone trying to cope with stress.

Calm-PRT Ingredients

Calm-PRT includes the following ingredients: Rhodiola Rosea root extract (standardized to 16% rosavins), SerinAid 50P (Phosphatidylserine enriched soy lecithin), Glycine, Taurine, vegetable cellulose (vegetarian capsules), rice flour, and magnesium stearate.

Product Features

Calm-PRT is a combination of herbs, amino acids and other nutrients designed to fight stress. The formula contains Phosphatidylserine, a substance naturally found in the brain in high concentrations. This is a fatty acid believed to play an important role in neuro-transmission. Decreased levels of Phosphatidylserine caused by aging processes or other causes have been linked to memory impairment, depression, Parkinson’s and Alzheimer’s disease. This is why the substance holds some promise as a potential prevention treatment for these conditions. Phosphatidylserine use may cause insomnia and stomach upset.

Rhodiola Rosea is a remarkable plant with a variety of uses throughout history. Particularly known for its adaptogenic and tonic properties, the plant has been used to strengthen the nervous system and fight depression, improve energy levels and memory, increase sexual function, assist with weight loss and enhance immunity to name just a few of its benefits.
There is ongoing research that seems to indicate Rhodiola helps alleviate symptoms of fatigue, insomnia and anxiety disorders such as post traumatic stress disorder, social phobia and social anxiety. There is concern that Rhodiola Rosea might interfere with blood pressure medication, and hence cause dizziness and vertigo. There is one study which seems to indicate that the plant may worsen symptoms of anxiety, requiring further investigation.

The recommended daily dosage of Calm-PRT is 3-4 capsules one to two times daily. Pregnant and nursing women should consult a specialist before use. Consumer experience with the product has generally been positive, however there are several negative opinions posted online.

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  • Calm-PRT contains no wheat, corn, soy, salt, sucrose, starch, yeast, artificial flavors, artificial colorings, or other known allergens
  • The main ingredients have been researched and documented evidence of their effectiveness exists
  • Generally positive consumer reviews available online


  • Small number of consumer reviews
  • Expensive formula, given that a month’s supply may cost as much as $100
  • Caution advised to certain categories of patients


The adrenal glands, and consequently Cortisol, Epinephrine and Norepinephrine play an essential part in the body’s response to stress. When under stress, the adrenal glands start secretion of these hormones which regulate how the body reacts to stress. However, many stressed individuals or those who are subject to long periods of stress have inadequate adrenal Cortisol production which can lead to exacerbated levels of stress. Calm-PRT desires to reduce over secretion and promote a normal, healthy response in stress related conditions. The formula has received positive consumer reviews, although not many. It is likely that the formula will work as advertised, however you should be cautious as some ingredients are known to cause side effects.

Review Box – Show On Page,Stress ReliefCalm-PRT Review
Calm-PRT Reviewbreditor2.752016-05-14 12:09:31
Calm-PRT Review
3.67 out of 5 based on 6 user ratings
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[Total: 3    Average: 3.3/5]

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3 User Reviews about Calm-PRT
  1. 1

    Kimberly Flores

    Calm-PRT was recommended to me by my doctor because I couldn’t sleep while going through a very stressful period. It helped me feel more calm and balanced. I could sleep better, without feeling groggy the morning after. I always a bottle in the house for emergency cases, but I’m not sure about taking Calm-PRT daily, without interruptions.

  2. 2

    What is the best 2 times to take the 3 CalmPRT. I am not sure and have been told 2 different things from 2 people. I suffer high nighttime cortisol and tend to wake every 2 hrs all night long.

    • 3

      Luann- My cortisol was high at night [about 2-3 oclock i would wake and be unable to go back to sleep sometimes]. My ND found insulin-resistance and recommended dietary changes. I’ve also used calm-prt for nearly 2 yrs. 3-4 capsules before supper [empty stomach] and it helps me destress and wind-down so i can sleep. hate spending so much but cant seem to do without it. what i eat all day seems to be important too- staying away from caffeine helpsj-tho it can be really hard. I also react badly to valerian -which is supposed to be relaxing- it does not help me sleep. hope this helps.